C-C Motif Ligand 21/C-C Motif Chemokine Receptor 7 Modulated Tumor Properties for Non-Small Cell Lung Cancer Brain Metastasis Patients

The non-small cell lung cancer is a common malignancy with high metastasis capacity. brain the primary site for patients unclear mechanism. Here, in this study, we hypothesized an innovative signaling cascade disorder and systematically investigated underlying Their differentially gene expression analysis was based on 13 conventional nonsmall 15 respectively. line, adenocarcinomic human alveolar basal epithelial cells-A549 bronchial line-BEAS-2B were established vitro study. syngeneic mouse tumor models injected 5×105 cells of control, C-C motif ligand 21 overexpressing, chemokine receptor 7 overexpressing A549 generated vivo analysis. Compared patients, showed 352 expressed genes, as 212 down-regulated ones 140 up-regulated ones. Moreover, prominently inhibited patients. In cells, could inhibit epithelial-mesenchymal transition progression. modulated migration plus invasion ability but not proliferation capacity through dependent pathway, Janus kinase 2/signal transducer activator transcription 3 potential downstream pathway. 21/C-C axis modulate growth survival time vivo. Collectively, these data initiated 7-Janus metastasis, which shed various beneficial insights future